Fatty Acid Oxidation
Free Fatty Acid Activation with CoA
Oxidation Occurs in Mitochondrial Matrix
Which Molecules Can Diffuse and Which Cannot:
Can Diffuse:
Cannot Diffuse:
Free Fatty Acid Transport
Steps in Beta Oxidation
Steps:
Products:
Similarities to Citric Acid Cycle:
Saturated vs Unsaturated
Melting Point ( Lowest to Highest )
Odd-Number Chain
Energy Generation for All Possible Combinations
Why Fatty acid synthesis?
Acetyl-CoA transport
Molecules involved
How NADPH is generated
Differences between Fatty acid oxidation and synthesis
How is Malonyl-CoA formed and why is it necessary?
What is a Phosphopantetheine moiety and how are fatty acids attached?
How many cycles to make palmitate
7
Quantities of reactants and products used/generated
FA Elongation
Desaturation
Essential fatty acids
Regulation of ACC and pyruvate dehydrogenase
Acetyl-CoA Carboxylase (ACC) is Regulated By:
Pyruvate Dehydrogenase is Regulated By:
General statistics about heart disease
Atherosclerosis
Define it
hardening of the arteries over the course of several decades
Role of macrophages and how they got there
Foam cells
Fatty streak
Fibrous cap
Possible result of thrombosis
Why cholesterol is such a concern
If no tissues require cholesterol the LDL will continue to circulate, eventually depositing the excess fat on the arterial walls
Medical diagnosis of LDL and HDL
LDL receptor complications and results
Hyperlipoproteinemia
General characteristics
Symptoms
Properties and functions of membranes
General membrane constituents and their organization
Fluid mosaic model and fluidity
Differential content of proteins in membranes
Similarities and differences between membrane protein types
Differences between transmembrane, lipid-linked, and peripheral proteins
Transmembrane / Integral / Intrinsic
Lipid- Linked / Anchored
Peripheral / Extrinsic