Compare and contrast tryacylglycerols, glycerophospholipids, and Sphinolipids
a. Look at overall structure
b. Look at individual components
c. Look at chemical properties
Using your analysis from Q1 , identify the main differences between the molecular groups above
a. Triacylglycerols and glycerophospholipids
b. Triacylglycerols and sphinogolipids
c. Glycerophospholipids and sphinogolipids
Triglyceride
https://en.wikipedia.org/wiki/Triglyceride
Glycerophospholipids
https://en.wikipedia.org/wiki/Glycerophospholipid
Sphinolipids
https://en.wikipedia.org/wiki/Sphingolipid
1.A. How is glycerol-3-phosphate made using glycerol?
1.B. How is glycerol-3-phosphate made using intermediates in central metabolism? What metabolic pathway is this similar to? How is it different?
https://en.wikipedia.org/wiki/Glycerol_3-phosphate
1.C. Which method is used in adipocytes and why?
2.A. What class of lipids are generated in this step?
https://en.wikipedia.org/wiki/Phosphatidic_acid
2.B. Are the fatty acids activated? How do you know?
4.A. What are the six main phospholipid classes found in our membranes?
https://en.wikipedia.org/wiki/Membrane_lipid#Major_classes
- Phospholipids
- Glycolipids
- Fatty Acids
- Phosphoglycerides
- Sphinogolipids
- Sterols
4.B. How are these classes similar and different from phosphatidic acids?
5.A. How is the phosphatidic acid activated?
5.B. Where does the molecule join the phosphatidic acid?
- On the phosphate
7.A. Compare the structures of phosphatidylserine and phosphatidylethanolamine, how could one be converted to the other?
- Carboxylate alpha carbon
7.B. Compare the structures of PE and PC. What are the differences?
- Choline is all methylated
- Phosphatidylcholine can also be produced by three successive methylations of phosphatidyl-ethanolamine
- The methyl group donor in this pathway is an activated derivative of methionine, S-adenosyl-l-methionine (AdoMet).
7.C. To make PG and CL a glycerol-3-phophate is added to the CDP-diacylglycerol. Compare cardiolipin and PG. What is added to PG to make CL?
https://en.wikipedia.org/wiki/Cardiolipin
https://www.easybiologyclass.com/biochemistry-membrane-lipids-properties-structure-classification/
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